Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
نویسندگان
چکیده
منابع مشابه
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity.
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because intercellular heterogeneity is often found in neoplastic tissues, we investigated the occurrence of BFB events in human solid tumors. Evidence of frequent BFB events was found in malignancies that showed un...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.090013497